Structure of PDB 4zqo Chain A

Receptor sequence
>4zqoA (length=354) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
DPVPTGGDDPHKVAMLGLTFDDVLLLPAASDVVPATADTSSQLTKKIRLK
VPLVSSAMDTVTESRMAIAMARAGGMGVLHRNLPVAEQAGQVEMVKRSGG
LLVGAAVGVGGDAWVRAMMLVDAGVDVLVVDTAHAHNRLVLDMVGKLKSE
VGDRVEVVGGNVATRSAAAALVDAGADAVKVGVGPGSICTTRVVAGVGAP
QITAILEAVAACRPAGVPVIADGGLQYSGDIAKALAAGASTAMLGSLLAG
TAEAPGELIFVNGKQYKSYRGMGSLGAMRGKLVPEGIEGRVPFRGPLSSV
IHQLTGGLRAAMGYTGSPTIEVLQQAQFVRITPAGLKESHPHDVAMTVEA
PNYY
3D structure
PDB4zqo Mycobacterium tuberculosis IMPDH in Complexes with Substrates, Products and Antitubercular Compounds.
ChainA
Resolution1.76 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.205: IMP dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IMP A S83 M85 G338 S339 I340 C341 D374 G376 G397 S398 Y421 G423 M424 G425 E458 S56 M58 G186 S187 I188 C189 D222 G224 G245 S246 Y269 G271 M272 G273 E285
BS02 Q67 A A285 N289 M424 G425 L455 E458 A133 N137 M272 G273 L282 E285 MOAD: Ki=14nM
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0003938 IMP dehydrogenase activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0006164 purine nucleotide biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4zqo, PDBe:4zqo, PDBj:4zqo
PDBsum4zqo
PubMed26440283
UniProtP9WKI7|IMDH_MYCTU Inosine-5'-monophosphate dehydrogenase (Gene Name=guaB)

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