Structure of PDB 4zqm Chain A

Receptor sequence
>4zqmA (length=333) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
DPVPTGGDDPHKVAMLGLTFDDVLLLPAASDVVPATADTSSQLTKKIRLK
VPLVSSAMDTVTESRMAIAMARAGGMGVLHRNLPVAEQAGQVEMVKRSGG
LLVGAAVGVGGDAWVRAMMLVDAGVDVLVVDTAHAHNRLVLDMVGKLKSE
VGDRVEVVGGNVATRSAAAALVDAGADAVKVGVGPGSICTTRVVAGVGAP
QITAILEAVAACRPAGVPVIADGGLQYSGDIAKALAAGASTAMLGSLLAG
TAEAPGELIFVNGKQYKSYRGMGSLGAMLVPEGIEGRVPFRGPLSSVIHQ
LTGGLRAAMGYTGSPTIEVLQQAQFVRITPAGL
3D structure
PDB4zqm Mycobacterium tuberculosis IMPDH in Complexes with Substrates, Products and Antitubercular Compounds.
ChainA
Resolution1.602 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 1.1.1.205: IMP dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 XMP A S83 M85 G338 S339 I340 C341 D374 G376 G397 S398 Y421 G423 M424 G425 E458 S56 M58 G186 S187 I188 C189 D222 G224 G245 S246 Y269 G271 M272 G273 E282
BS02 NAD A R108 D283 T284 A285 H286 N289 M424 E458 R81 D131 T132 A133 H134 N137 M272 E282
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0003938 IMP dehydrogenase activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0006164 purine nucleotide biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4zqm, PDBe:4zqm, PDBj:4zqm
PDBsum4zqm
PubMed26440283
UniProtP9WKI7|IMDH_MYCTU Inosine-5'-monophosphate dehydrogenase (Gene Name=guaB)

[Back to BioLiP]