Structure of PDB 4zql Chain A

Receptor sequence
>4zqlA (length=177) Species: 9606 (Homo sapiens) [Search protein sequence]
MNEDWCAVCQNGGELLCCEKCPKVFHLSCHVPTLTNFPSGEWICTFCRDL
SKPEVEYDCDAKKKTEGLVKLTPIDKRKCERLLLFLYCHEMSLAFQDPVP
LTVPDYYKIIKNPMDLSTIKKRLQEDYSMYSKPEDFVADFRLIFQNCAEF
NEPDSEVANAGIKLENYFEELLKNLYP
3D structure
PDB4zql Crystal structure of TRIM24 with 3,4-dimethoxy-N-(6-(4-methoxyphenoxy)-1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)benzenesulfonamide inhibitor
ChainA
Resolution1.79 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C829 C832 H849 C852 C6 C9 H26 C29
BS02 ZN A C841 C844 C867 C870 C18 C21 C44 C47
External links
PDB RCSB:4zql, PDBe:4zql, PDBj:4zql
PDBsum4zql
PubMed
UniProtO15164|TIF1A_HUMAN Transcription intermediary factor 1-alpha (Gene Name=TRIM24)

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