Structure of PDB 4zp0 Chain A

Receptor sequence
>4zp0A (length=392) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
ARLGRQALLFPLCLVLYEFSTYIGNDMIQPGMLAVVEQYQAGIDWVPTSM
TAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQF
TLLRFLQGISLCFIGAVGYAAIRESFEEAVCIKITALMANVALIAPLLGP
LVGAAWIHVLPWEGMFVLFAALAAISFFGLQRAMPETATRIGEKLSLKEL
GRDYKLVLKNGRFVAGALALGFVSLPLLAWIAQSPIIIITGEQLSSYEYG
LLQVPIFGALIAGNLLLARLTSRRTVRSLIIMGGWPIMIGLLVAAAATVI
SSHAYLWMTAGLSIYAFGIGLANAGLVRLTLFASDMSKGTVSAAMGMLQM
LIFTVGIEISKHAWLNGGNGLFNLFNLVNGILWLSLMVIFLK
3D structure
PDB4zp0 Substrate-bound structure of the E. coli multidrug resistance transporter MdfA
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DXC A D34 L62 P154 L236 M358 D26 L54 P146 L228 M350
Gene Ontology
Molecular Function
GO:0015385 sodium:proton antiporter activity
GO:0015386 potassium:proton antiporter activity
GO:0022857 transmembrane transporter activity
Biological Process
GO:0030641 regulation of cellular pH
GO:0035725 sodium ion transmembrane transport
GO:0046677 response to antibiotic
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
GO:1902600 proton transmembrane transport
GO:1990961 xenobiotic detoxification by transmembrane export across the plasma membrane
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Biological Process
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Cellular Component
External links
PDB RCSB:4zp0, PDBe:4zp0, PDBj:4zp0
PDBsum4zp0
PubMed26238402
UniProtP0AEY8|MDFA_ECOLI Multidrug transporter MdfA (Gene Name=mdfA)

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