Structure of PDB 4zom Chain A

Receptor sequence
>4zomA (length=223) Species: 9606 (Homo sapiens) [Search protein sequence]
ASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMW
EMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVR
MCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSE
DEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILA
KLPPKGKLRSLCSQHVERLQIFQ
3D structure
PDB4zom Discovery of novel pyrazole-containing benzamides as potent ROR gamma inverse agonists.
ChainA
Resolution2.27 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4Q3 A W317 C320 H323 M365 F378 E379 F388 L391 C393 I397 I400 F401 H479 W53 C56 H59 M101 F114 E115 F124 L127 C129 I133 I136 F137 H215 MOAD: ic50=3nM
PDBbind-CN: -logKd/Ki=8.52,IC50=3nM
BindingDB: EC50=10.0nM,IC50=4.9nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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External links
PDB RCSB:4zom, PDBe:4zom, PDBj:4zom
PDBsum4zom
PubMed26048789
UniProtP51449|RORG_HUMAN Nuclear receptor ROR-gamma (Gene Name=RORC)

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