Structure of PDB 4zl4 Chain A

Receptor sequence
>4zl4A (length=395) Species: 5855 (Plasmodium vivax) [Search protein sequence]
KDLLYKYKLYGDIDEYAYYFLDIDIGTPEQRISLILDTGSSSLSFPCAGC
KNCGVHMENPFNLNNSKTSSILYCENEECPFKLNCVKGKCEYMQSYCEGS
QISGFYFSDVVSVVSYNNERVTFRKLMGCHMHEESLFLYQQATGVLGMSL
SKPQGIPTFVNLLFDNAPQLKQVFTICISENGGELIAGGYDPAYIVRAEK
VVWENVTRKYYYYIKVRGLDMFGTNMMSSSKGLEMLVDSGSTFTHIPEDL
YNKLNYFFDILCIQDMNNAYDVNKRLKMTNESFNNPLVQFDDFRKSLKSI
IAKENMCVKIVDGVQCWKYLEGLPDLFVTLSNNYKMKWQPHSYLYKKESF
WCKGIEKQVNNKPILGLTFFKNRQVIFDIQKNRIGFVDANCPSHP
3D structure
PDB4zl4 Structural basis for plasmepsin V inhibition that blocks export of malaria proteins to human erythrocytes.
ChainA
Resolution2.37 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.23.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4PK A A60 D80 G82 Y139 C140 E141 L179 F180 Q183 D313 G315 S316 T317 A17 D37 G39 Y96 C97 E98 L136 F137 Q140 D238 G240 S241 T242 MOAD: Kd=13.8nM
PDBbind-CN: -logKd/Ki=7.86,Kd=13.8nM
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4zl4, PDBe:4zl4, PDBj:4zl4
PDBsum4zl4
PubMed26214367
UniProtA5K302|PLM5_PLAVS Plasmepsin V (Gene Name=PMV)

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