Structure of PDB 4zk6 Chain A

Receptor sequence
>4zk6A (length=299) Species: 70601 (Pyrococcus horikoshii OT3) [Search protein sequence]
MDLVEEILRLKEERNAIILAHNYQLPEVQDIADFIGDSLELARRATRVDA
DVIVFAGVDFMAETAKILNPDKVVLIPSREATCAMANMLKVEHILEAKRK
YPNAPVVLYVNSTAEAKAYADVTVTSANAVEVVKKLDSDVVIFGPDKNLA
HYVAKMTGKKIIPVPSKGHCYVHQKFTLDDVERAKKLHPNAKLMIHPECI
PEVQEKADIIASTGGMIKRACEWDEWVVFTEREMVYRLRKLYPQKKFYPA
REDAFCIGMKAITLKNIYESLKDMKYKVEVPEEIARKARKAIERMLEMS
3D structure
PDB4zk6 Structure of Quinolinate Synthase from Pyrococcus horikoshii in the Presence of Its Product, Quinolinic Acid.
ChainA
Resolution1.895 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.72: quinolinate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SF4 A Y23 C83 M85 C170 C256 Y23 C83 M85 C170 C256
BS02 NTM A H21 Y23 S38 Y109 N111 H173 H196 E198 H21 Y23 S38 Y109 N111 H173 H196 E198
Gene Ontology
Molecular Function
GO:0008987 quinolinate synthetase A activity
GO:0016740 transferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0009435 NAD biosynthetic process
GO:0019363 pyridine nucleotide biosynthetic process
GO:0019805 quinolinate biosynthetic process
GO:0034628 'de novo' NAD biosynthetic process from aspartate
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:4zk6, PDBe:4zk6, PDBj:4zk6
PDBsum4zk6
PubMed27224840
UniProtO57767|NADA_PYRHO Quinolinate synthase (Gene Name=nadA)

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