Structure of PDB 4zk5 Chain A

Receptor sequence
>4zk5A (length=286) Species: 9606 (Homo sapiens) [Search protein sequence]
SLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEI
KLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDL
VKNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAE
VKLVDFGVSANTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIE
MAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYM
QRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRK
3D structure
PDB4zk5 Structure-Based Design of GNE-495, a Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal Angiogenesis.
ChainA
Resolution2.89 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D153 K155 Q157 N158 D171 T191
Catalytic site (residue number reindexed from 1) D137 K139 Q141 N142 D155 T166
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A S77 H79 I82 T84 S61 H63 I66 T68
BS02 4P4 A V31 Y36 V39 K41 A52 K54 M105 F107 C108 G109 G111 L160 V170 D171 V15 Y20 V23 K25 A36 K38 M89 F91 C92 G93 G95 L144 V154 D155 PDBbind-CN: -logKd/Ki=8.43,IC50=3.7nM
BindingDB: IC50=3.7nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:4zk5, PDBe:4zk5, PDBj:4zk5
PDBsum4zk5
PubMed26288693
UniProtO95819|M4K4_HUMAN Mitogen-activated protein kinase kinase kinase kinase 4 (Gene Name=MAP4K4)

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