Structure of PDB 4zk0 Chain A

Receptor sequence
>4zk0A (length=367) Species: 9606 (Homo sapiens) [Search protein sequence]
SLSEANTKFMFDLFQQFRKSKENNIFYSPISITSALGMVLLGAKDNTAQQ
IKKVLHFDQVTEGNVHHQFQKLLTEFNKSTDAYELKIANKLFGEKTYLFL
QEYLDAIKKFYQTSVESVDFANAPEESRKKINSWVESQTNEKIKNLIPEG
NIGSNTTLVLVNAIYFKGQWEKKFNKEDTKEEKFWPNKNTYKSIQMMRQY
TSFHFASLEDVQAKVLEIPYKGKDLSMIVLLPNEIDGLQKLEEKLTAEKL
MEWTSLQNMRETRVDLHLPRFKVEESYDLKDTLRTMGMVDIFNGDADLSG
MTGSRGLVLSGVLHKAFVEVTEEGAEAAAATAVVGFNEEFHCNHPFLFFI
RQNKTNSILFYGRFSSP
3D structure
PDB4zk0 Psoriasis pathogenesis - Pso p27 constitutes a compact structure forming large aggregates.
ChainA
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A D281 H283 D265 H267
BS02 ZN A H220 E277 H204 E261
Gene Ontology
Molecular Function
GO:0001618 virus receptor activity
GO:0002020 protease binding
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0004869 cysteine-type endopeptidase inhibitor activity
GO:0005515 protein binding
Biological Process
GO:0008284 positive regulation of cell population proliferation
GO:0010466 negative regulation of peptidase activity
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010950 positive regulation of endopeptidase activity
GO:0010951 negative regulation of endopeptidase activity
GO:0030335 positive regulation of cell migration
GO:0035425 autocrine signaling
GO:0038001 paracrine signaling
GO:0043086 negative regulation of catalytic activity
GO:0043508 negative regulation of JUN kinase activity
GO:0045861 negative regulation of proteolysis
GO:0046718 symbiont entry into host cell
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0031410 cytoplasmic vesicle
GO:0031982 vesicle
GO:0035578 azurophil granule lumen
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4zk0, PDBe:4zk0, PDBj:4zk0
PDBsum4zk0
PubMed29124154
UniProtP29508|SPB3_HUMAN Serpin B3 (Gene Name=SERPINB3)

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