Structure of PDB 4zjw Chain A

Receptor sequence
>4zjwA (length=219) Species: 9606 (Homo sapiens) [Search protein sequence]
TEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMW
ERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCR
AYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEI
ALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLP
PKGKLRSLCSQHVERLQIF
3D structure
PDB4zjw Discovery of biaryl carboxylamides as potent ROR gamma inverse agonists.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4P1 A Q286 H323 M365 F378 E379 F388 I400 V480 Q19 H56 M98 F111 E112 F121 I133 V213 MOAD: ic50=0.1uM
PDBbind-CN: -logKd/Ki=6.66,IC50=0.22uM
BindingDB: IC50=100nM,EC50=200nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4zjw, PDBe:4zjw, PDBj:4zjw
PDBsum4zjw
PubMed26048806
UniProtP51449|RORG_HUMAN Nuclear receptor ROR-gamma (Gene Name=RORC)

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