Structure of PDB 4zjr Chain A

Receptor sequence
>4zjrA (length=217) Species: 9606 (Homo sapiens) [Search protein sequence]
ASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMW
EMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVR
MCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSE
DEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILA
KLPPKGKLRSLCSQHVE
3D structure
PDB4zjr Discovery of biaryl carboxylamides as potent ROR gamma inverse agonists.
ChainA
Resolution2.702 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4P3 A W317 C320 H323 L324 M365 F378 E379 F388 I397 I400 F401 W53 C56 H59 L60 M101 F114 E115 F124 I133 I136 F137 PDBbind-CN: -logKd/Ki=7.54,IC50=0.029uM
BindingDB: EC50=93nM,IC50=11nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4zjr, PDBe:4zjr, PDBj:4zjr
PDBsum4zjr
PubMed26048806
UniProtP51449|RORG_HUMAN Nuclear receptor ROR-gamma (Gene Name=RORC)

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