Structure of PDB 4zi9 Chain A

Receptor sequence

>4zi9A (length=309) Species: 10090 (Mus musculus)

NIRYSVPEETDKGSFVGSIAKDLGLETRELMERGIRIVSRGRSQLFSLNP
RSGSLVTAGRIDREELCAQSTPCVVSFNILMEDEMKLLPIEVEIIDINDN
TPQFQLEELELKMSEITTPGTRIPLPLGQDLDVGINSLQSYQLSANPHFS
LDVQQGPEGPQQPEMVLQRPLDREKDAVHYLVLTASDGGSPIHSGTLQIH
VQVVDVNDNPPAFTKAEYHVSVPENVPLGTRLLKVNATDPDEGANGRVTY
SFHKVDHSVVRKFQLDAYTGELSNKEPLDFEEYKVYPMEIQAQDGAGLMA
RAKVLVTVL

3D structure

• PDB: 4zi9 Structure and Sequence Analyses of Clustered Protocadherins Reveal Antiparallel Interactions that Mediate Homophilic Specificity.
• Chain: A
• Resolution: 1.7 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA	A	N208 N210 D240 D242 N246 D295	N207 N209 D239 D241 N245 D294
BS02	CA	A	E116 E175 D206 V207 D209 D242	E115 E174 D205 V206 D208 D241
BS03	CA	A	E116 D173 E175 D209	E115 D172 E174 D208
BS04	CA	A	E9 E65 D97 I98 D100 D133	E8 E64 D96 I97 D99 D132
BS05	CA	A	N99 N101 D131 D133 N137 D188	N98 N100 D130 D132 N136 D187
BS06	CA	A	E9 E10 D63 E65 D100	E8 E9 D62 E64 D99

Gene Ontology

Molecular Function

• GO:0005509 calcium ion binding

Biological Process

• GO:0007155 cell adhesion
• GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:4zi9, PDBe:4zi9, PDBj:4zi9
• PDBsum: 4zi9
• PubMed: 26481813
• UniProt: Q91XZ0