Structure of PDB 4zi0 Chain A

Receptor sequence
>4zi0A (length=181) Species: 211044 (Influenza A virus (A/Puerto Rico/8/1934(H1N1))) [Search protein sequence]
GPLGSMEDFVRQCFNPMIVELAEKTMKEYGEDLKIETNKFAAICTHLEVC
FMYSDASKHRFEIIEGRDRTMAWTVVNSICNTTGAEKPKFLPDLYDYKEN
RFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDE
ESRARIKTRLFTIRQEMASRGLWDSFRQSER
3D structure
PDB4zi0 Two Distinctive Binding Modes of Endonuclease Inhibitors to the N-Terminal Region of Influenza Virus Polymerase Acidic Subunit
ChainA
Resolution1.802 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A H41 D108 E119 I120 H46 D93 E104 I105
BS02 MN A E80 D108 E65 D93
BS03 4P9 A K34 A37 T123 F150 F191 S194 E195 K39 A42 T108 F135 F176 S179 E180 BindingDB: IC50=8300nM
Gene Ontology
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:4zi0, PDBe:4zi0, PDBj:4zi0
PDBsum4zi0
PubMed27088785
UniProtP03433|PA_I34A1 Polymerase acidic protein (Gene Name=PA)

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