Structure of PDB 4zgy Chain A

Receptor sequence
>4zgyA (length=383) Species: 9606 (Homo sapiens) [Search protein sequence]
TAKDILDQKINEKDAFYVADLGDILKKHLRWLKALPRVTPFYAVKCNDSK
AIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQIKYAA
NNGVQMMTFDSEVELMKVARAHPKAKLVLRIATDDSCRLSVKFGATLRTS
RLLLERAKELNIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGF
SMYLLDIGGGFPGSEDVKLKFEEITGVINPALDKYFPSDSGVRIIAEPGR
YYVASAFTLAVNIIAKKIVLKEQTGSSEQTFMYYVNDGVYGSFNCILYDH
AHVKPLLQKRPEKYYSSSIWGPTCDGLDRIVERCDLPEMHVGDWMLFENM
GAYTVASTFNGFQRPTIYYVMSGPAWQLMQQFQ
3D structure
PDB4zgy Structural basis of antizyme-mediated regulation of polyamine homeostasis
ChainA
Resolution2.63 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K69 H197 E274
Catalytic site (residue number reindexed from 1) K45 H170 E247
Enzyme Commision number 4.1.1.17: ornithine decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP A K69 D88 H197 G237 E274 G276 R277 Y389 K45 D64 H170 G210 E247 G249 R250 Y353
BS02 MG A G237 F238 R277 Y278 G210 F211 R250 Y251
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004586 ornithine decarboxylase activity
GO:0005515 protein binding
GO:0016831 carboxy-lyase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0001822 kidney development
GO:0006595 polyamine metabolic process
GO:0006596 polyamine biosynthetic process
GO:0008283 cell population proliferation
GO:0008284 positive regulation of cell population proliferation
GO:0009615 response to virus
GO:0033387 putrescine biosynthetic process from ornithine
GO:0042176 regulation of protein catabolic process
Cellular Component
GO:0005575 cellular_component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4zgy, PDBe:4zgy, PDBj:4zgy
PDBsum4zgy
PubMed26305948
UniProtP11926|DCOR_HUMAN Ornithine decarboxylase (Gene Name=ODC1)

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