Structure of PDB 4zdq Chain A

Receptor sequence
>4zdqA (length=230) Species: 271848 (Burkholderia thailandensis E264) [Search protein sequence]
TSRLFALIPCAGTGSRSGSALPKQYRTLAGRALLHYTLAAFDACSEFAQT
LVVISPDDAHFDARRFAGLRFAVRRCGGASRQASVMNGLIQLAEFGATDA
DWVLVHDAARPGITPALIRTLIGALKDDPVGGIVALPVADTLKRVPAGGD
AIERTESRNGLWQAQTPQMFRIGMLRDAIQRAQLEGRDLTDEASAIEWAG
HTPRVVQGSLRNFKVTYPEDFDLAEAILAH
3D structure
PDB4zdq Crystal Structure of 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (IspD) from Burkholderia thailandensis complexed with CTP
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.60: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CTP A P10 C11 A12 G13 T14 G15 S16 R17 K24 A80 S81 R82 S85 D108 A109 K215 P9 C10 A11 G12 T13 G14 S15 R16 K23 A79 S80 R81 S84 D107 A108 K214
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0016779 nucleotidyltransferase activity
GO:0050518 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GO:0070567 cytidylyltransferase activity
Biological Process
GO:0008299 isoprenoid biosynthetic process
GO:0019288 isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:4zdq, PDBe:4zdq, PDBj:4zdq
PDBsum4zdq
PubMed38305785
UniProtQ2SWT6|ISPD_BURTA 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (Gene Name=ispD)

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