Structure of PDB 4zdk Chain A

Receptor sequence
>4zdkA (length=534) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
TATKHLFVSGGVASSLGKGLTASSLGQLLTARGLHVTMQKLDPYLNVDPG
TMNPFQHGEVFVTEDGAETDLDVGHYERFLDRNLPGSANVTTGQVYSTVI
AKERRGEYLGDTVQVIPHITDEIKRRILAMAQPDADGNRPDVVITEIGGT
VGDIESQPFLEAARQVRHYLGREDVFFLHVSLVPYLAPSGELKTKPTQHS
VAALRSIGITPDALILRCDRDVPEALKNKIALMCDVDIDGVISTPDAPSI
YDIPKVLHREELDAFVVRRLNLPFRDVDWTEWDDLLRRVHEPHETVRIAL
VGKYVELSDAYLSVAEALRAGGFKHRAKVEICWVASDGCETTSGAAAALG
DVHGVLIPGGFGIRGIEGKIGAIAYARARGLPVLGLCLGLQCIVIEAARS
VGLTNANSAEFDPDTPDPVIATMGGTMRLGSYPAVLEPDSVVAQAYQTTQ
VSERHRHRYEVNNAYRDKIAESGLRFSGTSPDGHLVEFVEYPPDRHPFVV
GTQAHPELKSRPTRPHPLFVAFVGAAIDYKAGEL
3D structure
PDB4zdk Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG.
ChainA
Resolution3.49 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.3.4.2: CTP synthase (glutamine hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ONL A G365 G366 F367 C393 Q397 E416 H476 Y478 G359 G360 F361 C387 Q391 E410 H457 Y459
BS02 ACP A S21 G23 K24 G25 L26 K46 E152 R223 D252 A253 I259 S15 G17 K18 G19 L20 K40 E146 R217 D246 A247 I253
BS03 UTP A S20 D159 I160 E161 S14 D153 I154 E155
BS04 MG A G25 D78 E152 G19 D72 E146
Gene Ontology
Molecular Function
GO:0003883 CTP synthase activity
GO:0004359 glutaminase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0006241 CTP biosynthetic process
GO:0006541 glutamine metabolic process
GO:0019856 pyrimidine nucleobase biosynthetic process
GO:0044210 'de novo' CTP biosynthetic process
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4zdk, PDBe:4zdk, PDBj:4zdk
PDBsum4zdk
PubMed26097035
UniProtP9WHK7|PYRG_MYCTU CTP synthase (Gene Name=pyrG)

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