Structure of PDB 4zcs Chain A

Receptor sequence
>4zcsA (length=141) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
KNVVIYADGVYDMLHLGHMKQLEQAKKLFENTTLIVGVTSDNETKLFKGQ
VVQTLEERTETLKHIRWVDEIISPCPWVVTPEFLEKYKIDYVAHDDIPYA
NNQKEDIYAWLKRAGKFKATQRTEGVSTTDLIVRILKNYED
3D structure
PDB4zcs Structural determinants of the catalytic mechanism of Plasmodium CCT, a key enzyme of malaria lipid biosynthesis.
ChainA
Resolution2.45 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) F662 G664
Catalytic site (residue number reindexed from 1) F47 G49
Enzyme Commision number 2.7.7.15: choline-phosphate cytidylyltransferase.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 CDC A D623 G624 V625 G632 Q636 T654 K663 W692 H709 D710 Y714 Y741 R755 T756 D8 G9 V10 G17 Q21 T39 K48 W77 H94 D95 Y99 Y108 R122 T123 PDBbind-CN: -logKd/Ki=4.33,Kd=47uM
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004105 choline-phosphate cytidylyltransferase activity
Biological Process
GO:0006657 CDP-choline pathway
GO:0009058 biosynthetic process

View graph for
Molecular Function

View graph for
Biological Process
External links
PDB RCSB:4zcs, PDBe:4zcs, PDBj:4zcs
PDBsum4zcs
PubMed30046154
UniProtQ8IEE9

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