Structure of PDB 4zcp Chain A

Receptor sequence
>4zcpA (length=129) Species: 5833 (Plasmodium falciparum) [Search protein sequence]
KNVVIYADGVYDMLHLGHMKQLEQAKKLFENTTLIVGVTSDNETKLFKGQ
VVQTLEERTETLKHIRWVDEIISPCPWVVTPEFLEKYKIDYVAHDDIDIY
AWLKRAGKFKATQRTEGVSTTDLIVRILK
3D structure
PDB4zcp Structural determinants of the catalytic mechanism of Plasmodium CCT, a key enzyme of malaria lipid biosynthesis.
ChainA
Resolution1.98 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) F662 G664
Catalytic site (residue number reindexed from 1) F47 G49
Enzyme Commision number 2.7.7.15: choline-phosphate cytidylyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C5P A G624 V625 Y626 H630 G632 H633 Q636 D710 R755 T756 G9 V10 Y11 H15 G17 H18 Q21 D95 R114 T115
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004105 choline-phosphate cytidylyltransferase activity
Biological Process
GO:0006657 CDP-choline pathway
GO:0009058 biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4zcp, PDBe:4zcp, PDBj:4zcp
PDBsum4zcp
PubMed30046154
UniProtQ8IEE9

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