Structure of PDB 4zcm Chain A

Receptor sequence

>4zcmA (length=561) Species: 83333 (Escherichia coli K-12)

MIEKLRNIAIIAHVDHGKTTLVDKLLQQSGTILAKNTAIKWNDYRINIVD
TPGHADFGGEVERVMSMVDSVLLVVDAFDGPMPQTRFVTKKAFAYGLKPI
VVINKVDRPGARPDWVVDQVFDLFVNLDATDEQLDFPIVYASALNGIAGL
DHEDMAEDMTPLYQAIVDHVPAPDVDLDGPFQMQISQLDYNSYVGVIGIG
RIKRGKVKPNQQVTIIDSEGKTRNAKVGKVLGHLGLERIETDLAEAGDIV
AITGLGELNISDTVCDTQNVEALPALSVDEPTVSMFFCVNTSPFCGKEGK
FVTSRQILDRLNKELVHNVALRVEETEDADAFRVSGRGELHLSVLIENMR
REGFELAVSRPKVIFREIDGRKQEPYENVTLDVEEQHQGSVMQALGERKG
DLKNMNPDGKGRVRLDYVIPSRGLIGFRSEFMTMTSGTGLLYSTFSHYDD
VRPGEVGQRQNGVLISNGQGKAVAFALFGLQDRGKLFLGHGAEVYEGQII
GIHSRSNDLTVNCLTVLVPPIRMTLEQALEFIDDDELVEVTPTSIRIRKR
HLTENDRRRAN

3D structure

• PDB: 4zcm Structural and Functional Analysis of BipA, a Regulator of Virulence in Enteropathogenic Escherichia coli.
• Chain: A
• Resolution: 3.31 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): D15 K18 T19 H78
• Catalytic site (residue number reindexed from 1): D15 K18 T19 H54
• Enzyme Commision number: 3.6.5.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	G4P	A	V14 D15 H16 G17 K18 T19 T20 N128 K129 S166 L168	V14 D15 H16 G17 K18 T19 T20 N104 K105 S142 L144

Gene Ontology

Molecular Function

• GO:0000049 tRNA binding
• GO:0003924 GTPase activity
• GO:0005525 GTP binding
• GO:0016787 hydrolase activity
• GO:0019843 rRNA binding
• GO:0043022 ribosome binding
• GO:0097216 guanosine tetraphosphate binding

Biological Process

• GO:0000027 ribosomal large subunit assembly
• GO:0005975 carbohydrate metabolic process
• GO:0042254 ribosome biogenesis

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:4zcm, PDBe:4zcm, PDBj:4zcm
• PDBsum: 4zcm
• PubMed: 26163516
• UniProt: P0A3B2|BIPA_ECO27 Large ribosomal subunit assembly factor BipA (Gene Name=bipA)