Structure of PDB 4zbi Chain A

Receptor sequence
>4zbiA (length=152) Species: 9606 (Homo sapiens) [Search protein sequence]
GDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGV
QRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISF
GAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFH
VE
3D structure
PDB4zbi Discovery of tricyclic indoles that potently inhibit mcl-1 using fragment-based methods and structure-based design.
ChainA
Resolution2.5 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4M6 A M250 V253 F254 R263 T266 L267 F270 G271 I294 M80 V83 F84 R93 T96 L97 F100 G101 I124 MOAD: Ki=0.31uM
PDBbind-CN: -logKd/Ki=6.51,Ki=0.31uM
BindingDB: Ki=310nM
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:4zbi, PDBe:4zbi, PDBj:4zbi
PDBsum4zbi
PubMed25844895
UniProtQ07820|MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 (Gene Name=MCL1)

[Back to BioLiP]