Structure of PDB 4za5 Chain A

Receptor sequence

>4za5A (length=499) Species: 5061 (Aspergillus niger)

QPAHLCFRSFVEALKVDNDLVEINTPIDPNLEAAAITRRVCETNDKAPLF
NNLIGMKNGLFRILGAPGSLRKSSADRYGRLARHLALPPTASMREILDKM
LSASDMPPIPPTIVPTGPCKENSLDDSEFDLTELPVPLIHKSDGGKYIQT
YGMHIVQSPDGTWTNWSIARAMVHDKNHLTGLVIPPQHIWQIHQMWKKEG
RSDVPWALAFGVPPAAIMASSMPIPDGVTEAGYVGAMTGSSLELVKCDTN
DLYVPATSEIVLEGTLSISETGPEGPFGEMHGYIFPGDTHLGAKYKVNRI
TYRNNAIMPMSSCGRLTDETHTMIGSLAAAEIRKLCQQNDLPITDAFAPF
ESQVTWVALRVDTEKLRAMKTTSEGFRKRVGDVVFNHKAGYTIHRLVLVG
DDIDVYEGKDVLWAFSTRCRPGMDETLFEDVRGFPLIPYMGHGNGPAHRG
GKVVSDALMPTEYTTGRNWEAADFNQSYPEDLKQKVLDNWTKMGFSHHH

3D structure

• PDB: 4za5 New cofactor supports alpha , beta-unsaturated acid decarboxylation via 1,3-dipolar cycloaddition.
• Chain: A
• Resolution: 1.1 Å

Enzymatic activity

• Enzyme Commision number: 4.1.1.102: phenacrylate decarboxylase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	4LU	A	T153 N168 I171 A172 R173 Q190 H191 S223 S224 M225 P226 I327 K391	T150 N165 I168 A169 R170 Q187 H188 S220 S221 M222 P223 I324 K388
BS02	FZZ	A	T153 N168 S170 I171 A172 Q190 H191 S223 S224 M225 I327 K391 T395 F437	T150 N165 S167 I168 A169 Q187 H188 S220 S221 M222 I324 K388 T392 F434
BS03	MN	A	N168 H191 E233	N165 H188 E230

Gene Ontology

Molecular Function

• GO:0016831 carboxy-lyase activity
• GO:0030145 manganese ion binding
• GO:0042802 identical protein binding
• GO:0046872 metal ion binding

Biological Process

• GO:0009074 aromatic amino acid family catabolic process
• GO:0018966 styrene metabolic process
• GO:0033494 ferulate metabolic process
• GO:0046281 cinnamic acid catabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:4za5, PDBe:4za5, PDBj:4za5
• PDBsum: 4za5
• PubMed: 26083754
• UniProt: A2QHE5|FDC1_ASPNC Ferulic acid decarboxylase 1 (Gene Name=fdc1)