Structure of PDB 4za0 Chain A

Receptor sequence
>4za0A (length=434) Species: 9606 (Homo sapiens) [Search protein sequence]
MSIEKIWAREILDSRGNPTVEVDLYTAKGLFRAAVPSGASTGIYEALELR
DGDKQRYLGKGVLKAVDHINSTIAPALISSGLSVVEQEKLDNLMLELDGT
ENKSKFGANAILGVSLAVCKAGAAERELPLYRHIAQLAGNSDLILPVPAF
NVINGGSHAGNKLAMQEFMILPVGAESFRDAMRLGAEVYHTLKGVIKDKY
GKDATNVGDEGGFAPNILENSEALELVKEAIDKAGYTEKIVIGMDVAASE
FYRDGKYDLDFKSPTDPSRYITGDQLGALYQDFVRDYPVVSIEDPFDQDD
WAAWSKFTANVGIQIVGDDLTVTNPKRIERAVEEKACNCLLLKVNQIGSV
TEAIQACKLAQENGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCR
SERLAKYNQLMRIEEELGDEARFAGHNFRNPSVL
3D structure
PDB4za0 SF2312 is a natural phosphonate inhibitor of enolase.
ChainA
Resolution2.31 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) S40 H158 E167 E210 D245 E293 D318 K343 H371 K394
Catalytic site (residue number reindexed from 1) S40 H158 E167 E210 D245 E293 D318 K343 H371 K394
Enzyme Commision number 4.2.1.11: phosphopyruvate hydratase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A D245 E293 D318 D245 E293 D318
BS02 PAH A G38 A39 S40 Q166 E167 D245 E293 D318 K343 R372 S373 K394 G38 A39 S40 Q166 E167 D245 E293 D318 K343 R372 S373 K394 PDBbind-CN: -logKd/Ki=7.21,IC50=62.3nM
BindingDB: IC50=62.3nM
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004634 phosphopyruvate hydratase activity
GO:0005515 protein binding
GO:0016829 lyase activity
GO:0046872 metal ion binding
Biological Process
GO:0006094 gluconeogenesis
GO:0006096 glycolytic process
GO:0061621 canonical glycolysis
Cellular Component
GO:0000015 phosphopyruvate hydratase complex
GO:0001917 photoreceptor inner segment
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0043025 neuronal cell body
GO:0043204 perikaryon
GO:0070062 extracellular exosome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4za0, PDBe:4za0, PDBj:4za0
PDBsum4za0
PubMed27723749
UniProtP09104|ENOG_HUMAN Gamma-enolase (Gene Name=ENO2)

[Back to BioLiP]