Structure of PDB 4z9g Chain A

Receptor sequence
>4z9gA (length=421) Species: 9606,10693 [Search protein sequence]
KSKVHYHVAAIINYLGHCISLVALLVAFVLFLRARSIRCLRNIIHANLIA
AFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEG
CYLHTAIVLTNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLSV
AKSELDKAIGRNSNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSL
DAVRRSALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQ
TPNRAKRVIATFRTGTWDAYLTDRLRAWMFICIGWGVPFPIIVAWAIGKL
YYDNEKCWAGKRPGVYTDYIYQGPMALVLLINFIFLFNIVRILMTKLRAS
TTSETIQARKAVKATLVLLPLLGITYMLAFVNPGEDEVSRVVFIYFNAFL
ESFQGFFVSVFACFLNSEVRS
3D structure
PDB4z9g Decoding Corticotropin-Releasing Factor Receptor Type 1 Crystal Structures.
ChainA
Resolution3.183 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E1011 D1020
Catalytic site (residue number reindexed from 1) E120 D129
Enzyme Commision number 3.2.1.17: lysozyme.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1Q5 A F203 G210 L280 N283 F284 L287 T316 L320 L323 F93 G100 L329 N332 F333 L336 T365 L369 L372
Gene Ontology
Molecular Function
GO:0003796 lysozyme activity
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G protein-coupled receptor activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0009253 peptidoglycan catabolic process
GO:0016998 cell wall macromolecule catabolic process
GO:0031640 killing of cells of another organism
GO:0042742 defense response to bacterium
GO:0044659 viral release from host cell by cytolysis
Cellular Component
GO:0016020 membrane
GO:0030430 host cell cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4z9g, PDBe:4z9g, PDBj:4z9g
PDBsum4z9g
PubMed28183242
UniProtC3V2B5;
P34998|CRFR1_HUMAN Corticotropin-releasing factor receptor 1 (Gene Name=CRHR1)

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