Structure of PDB 4z93 Chain A

Receptor sequence
>4z93A (length=112) Species: 9606 (Homo sapiens) [Search protein sequence]
KVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPM
DMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQD
VFEMRFAKMPDE
3D structure
PDB4z93 Structure-Based Design of gamma-Carboline Analogues as Potent and Specific BET Bromodomain Inhibitors.
ChainA
Resolution1.27 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4LD A W374 P375 F376 L385 C429 N433 V439 W26 P27 F28 L37 C81 N85 V91 MOAD: Kd=44.6nM
PDBbind-CN: -logKd/Ki=7.35,Kd=44.6nM
BindingDB: Kd=47nM,Ki=12nM,IC50=37nM
External links
PDB RCSB:4z93, PDBe:4z93, PDBj:4z93
PDBsum4z93
PubMed26080064
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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