Structure of PDB 4z69 Chain A

Receptor sequence

>4z69A (length=581) Species: 9606 (Homo sapiens) [Search protein sequence]

HKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKT
CVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECF
LQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAP
ELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCAS
LQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLE
CADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADL
PSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKT
YETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYK
FQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDY
LSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEF
NAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFA
AFVEKCCKADDKETCFAEEGKKLVAASQAAL

3D structure

PDB

4z69 Structural basis of non-steroidal anti-inflammatory drug diclofenac binding to human serum albumin.

Chain

Resolution

2.187 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	F15	A	R117 Y138 Y161 F165	R115 Y136 Y159 F163
BS02	PLM	A	F70 Y150 R257 A258 S287	F68 Y148 R255 A256 S285
BS03	F15	A	S342 V344 R348 L387 L453 R485	S340 V342 R346 L385 L451 R483
BS04	PLM	A	Y411 L460 F488 S489	Y409 L458 F486 S487
BS05	F15	A	Y401 F507 K525 L532 M548 F551 S579	Y399 F505 K523 L530 M546 F549 S577
BS06	DIF	A	I142 H146 F149 L154 Y161 R186 G189 K190	I140 H144 F147 L152 Y159 R184 G187 K188	BindingDB: Kd=2455nM,Ki=99999999999999nM
BS07	DIF	A	W214 R218 L219 R222 S287	W212 R216 L217 R220 S285	BindingDB: Kd=2455nM,Ki=99999999999999nM
BS08	DIF	A	S202 L203 F206 A210 F211 W214 V344 L481 V482	S200 L201 F204 A208 F209 W212 V342 L479 V480	BindingDB: Kd=2455nM,Ki=99999999999999nM

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0005504	fatty acid binding
GO:0005507	copper ion binding
GO:0005515	protein binding
GO:0008289	lipid binding
GO:0015643	toxic substance binding
GO:0016209	antioxidant activity
GO:0019825	oxygen binding
GO:0030170	pyridoxal phosphate binding
GO:0042802	identical protein binding
GO:0046872	metal ion binding
GO:0051087	protein-folding chaperone binding
GO:0140272	exogenous protein binding
GO:1903981	enterobactin binding

	Biological Process
GO:0009267	cellular response to starvation
GO:0051902	negative regulation of mitochondrial depolarization
GO:0072732	cellular response to calcium ion starvation
GO:0098869	cellular oxidant detoxification

	Cellular Component
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen
GO:0005794	Golgi apparatus
GO:0031093	platelet alpha granule lumen
GO:0032991	protein-containing complex
GO:0070062	extracellular exosome
GO:0072562	blood microparticle

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Molecular Function

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Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:4z69, PDBe:4z69, PDBj:4z69
PDBsum	4z69
PubMed	25958880
UniProt	P02768\|ALBU_HUMAN Albumin (Gene Name=ALB)

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