Structure of PDB 4z4p Chain A

Receptor sequence
>4z4pA (length=161) Species: 9606 (Homo sapiens) [Search protein sequence]
TLHSKSSQYRRLRTEWKNNVYLARSRIQGLGLYAAKDLEKHTMVIEYIGT
IIRNEVANRREKIYEEQNRGIYMFRINNEHVIDATLTGGPARYINHSCAP
NCVAEVVTFDKEDKIIIISSRRIPKGEELTYDYQFDFEDDQHEIPCHCGA
WNCRKWMKGHH
3D structure
PDB4z4p Evolving Catalytic Properties of the MLL Family SET Domain.
ChainA
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y5426 I5502
Catalytic site (residue number reindexed from 1) Y47 I123
Enzyme Commision number 2.1.1.364: [histone H3]-lysine(4) N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C5477 C5525 C5527 C5532 C98 C146 C148 C153
BS02 SAH A I5406 Q5407 G5408 L5409 Y5451 Y5472 N5474 H5475 Y5512 I5523 C5525 H5526 C5527 M5536 H5539 I27 Q28 G29 L30 Y72 Y93 N95 H96 Y133 I144 C146 H147 C148 M157 H160
External links
PDB RCSB:4z4p, PDBe:4z4p, PDBj:4z4p
PDBsum4z4p
PubMed26320581
UniProtO14686|KMT2D_HUMAN Histone-lysine N-methyltransferase 2D (Gene Name=KMT2D)

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