BioLiP

>4z4gA (length=799) Species: 9606 (Homo sapiens) [Search protein sequence]

AFKPPPRPDFGTSGRTIKLQANFFEMDIPKIDIYHYELDIKPEKCPRRVN
REIVEHMVQHFKTQIFGKPVFDGRKNLYTAMPLPIGRDKVELEVTLPIFK
VSIKWVSCVSLQALHDALSGRLPSVPFETIQALDVVMRHLPSMRYTPVGR
SFFTASEGCSNPLGGGREVWFGFHQSVRPSLWKMMLNIDVSATAFYKAQP
VIEFVCEVLDFKSIEEQQKPLTDSQRVKFTKEIKGLKVEIKRKYRVCNVT
RRPASHQTFCTVAQYFKDRHKLVLRYPHLPCLQVGQEQKHTYLPLEVCNI
VAGQRCIKKLTDNQTSTMIRATARSAPDRQEEISKLMRSADFNTDPYVRE
FGIMVKDEMTDVTGRVLQPPSILYGGRNKAIATPVQGVWDMRNKQFHTGI
EIKVWAIACFAPQRQCTEVHLKSFTEQLRKISRDAGMPIQGQPCFCKYAQ
GADSVEPMFRHLKNTYAGLQLVVVILPGKTPVYAEVKRVGDTVLGMATQC
VQMKNVQRTTPQTLSNLCLKINVKLGGVNNILLPQGRPPVFQQPVIFLGA
DVTHPPAGDGKKPSIAAVVGSMDAHPNRYCATVRVQQHRQEIIQDLAAMV
RELLIQFYKSTRFKPTRIIFYRDGVSEGQFQQVLHHELLAIREACIKLEK
DYQPGITFIVVQKRHHTRLFCTDKNERVGKSGNIPAGTTVDTKITHPTEF
DFYLCSHAGIQGTSRPSHYHVLWDDNRFSSDELQILTYQLCHTYVRCTRS
VSIPAPAYYAHLVAFRARYHLVDKEGRDHQALAKAVQVHQDTLRTMYFA

Site
#

Ligand

Ligand
chain

Binding residues on receptor
(original residue number in PDB)

Binding residues on receptor
(residue number reindexed from 1)

Binding affinity

BS01

rna

P67 R68 R97 G178 R179 F294 Y311 H336 Y338 L522 G524 T526 Y529 K533 Q545 C546 Q548 N551 T559 N562 K566 K570 H600 P601 P602 A603 R635 E637 S672 Q675 K709 R710 H753 Q757 S760 R761 Y790 R792 S798 Y804

P46 R47 R74 G149 R150 F259 Y265 H290 Y292 L476 G478 T480 Y483 K487 Q499 C500 Q502 N505 T513 N516 K520 K524 H554 P555 P556 A557 R589 E591 S626 Q629 K663 R664 H707 Q711 S714 R715 Y744 R746 S752 Y758

PDBbind-CN: Kd=1.7nM

BS02

rna

D358 S362 K525 Q558 K726 F811 Y815

D312 S316 K479 Q512 K680 F765 Y769

PDBbind-CN: Kd=1.7nM

BS03

D597 V598

D551 V552

Molecular Function

GO:0000340

RNA 7-methylguanosine cap binding

GO:0000993

RNA polymerase II complex binding

GO:0001046

core promoter sequence-specific DNA binding

GO:0003676

nucleic acid binding

GO:0003723

RNA binding

GO:0003725

double-stranded RNA binding

GO:0003727

single-stranded RNA binding

GO:0003729

mRNA binding

GO:0003743

translation initiation factor activity

GO:0004519

endonuclease activity

GO:0004521

RNA endonuclease activity

GO:0005515

protein binding

GO:0016891

RNA endonuclease activity, producing 5'-phosphomonoesters

GO:0035197

siRNA binding

GO:0035198

miRNA binding

GO:0035925

mRNA 3'-UTR AU-rich region binding

GO:0046872

metal ion binding

GO:0061980

regulatory RNA binding

GO:0070551

endoribonuclease activity, cleaving siRNA-paired mRNA

GO:0090624

endoribonuclease activity, cleaving miRNA-paired mRNA

GO:0098808

mRNA cap binding

	Biological Process
GO:0006355	regulation of DNA-templated transcription
GO:0006412	translation
GO:0006413	translational initiation
GO:0006417	regulation of translation
GO:0009791	post-embryonic development
GO:0010501	RNA secondary structure unwinding
GO:0010586	miRNA metabolic process
GO:0010628	positive regulation of gene expression
GO:0030422	siRNA processing
GO:0031047	regulatory ncRNA-mediated gene silencing
GO:0031054	pre-miRNA processing
GO:0033962	P-body assembly
GO:0035194	regulatory ncRNA-mediated post-transcriptional gene silencing
GO:0035196	miRNA processing
GO:0035278	miRNA-mediated gene silencing by inhibition of translation
GO:0035279	miRNA-mediated gene silencing by mRNA destabilization
GO:0042985	negative regulation of amyloid precursor protein biosynthetic process
GO:0045727	positive regulation of translation
GO:0045766	positive regulation of angiogenesis
GO:0045944	positive regulation of transcription by RNA polymerase II
GO:0045947	negative regulation of translational initiation
GO:0060213	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:0070922	RISC complex assembly
GO:0090128	regulation of synapse maturation
GO:0090625	siRNA-mediated gene silencing by mRNA destabilization
GO:1900153	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:1901165	positive regulation of trophoblast cell migration

Biological Process

GO:0006355

regulation of DNA-templated transcription

GO:0006412

translation

GO:0006413

translational initiation

GO:0006417

regulation of translation

GO:0009791

post-embryonic development

GO:0010501

RNA secondary structure unwinding

GO:0010586

miRNA metabolic process

GO:0010628

positive regulation of gene expression

GO:0030422

siRNA processing

GO:0031047

regulatory ncRNA-mediated gene silencing

GO:0031054

pre-miRNA processing

GO:0033962

P-body assembly

GO:0035194

regulatory ncRNA-mediated post-transcriptional gene silencing

GO:0035196

miRNA processing

GO:0035278

miRNA-mediated gene silencing by inhibition of translation

GO:0035279

miRNA-mediated gene silencing by mRNA destabilization

GO:0042985

negative regulation of amyloid precursor protein biosynthetic process

GO:0045727

positive regulation of translation

GO:0045766

positive regulation of angiogenesis

GO:0045944

positive regulation of transcription by RNA polymerase II

GO:0045947

negative regulation of translational initiation

GO:0060213

positive regulation of nuclear-transcribed mRNA poly(A) tail shortening

GO:0070922

RISC complex assembly

GO:0090128

regulation of synapse maturation

GO:0090625

siRNA-mediated gene silencing by mRNA destabilization

GO:1900153

positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

GO:1901165

positive regulation of trophoblast cell migration

	Cellular Component
GO:0000932	P-body
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane
GO:0016442	RISC complex
GO:0030425	dendrite
GO:0036464	cytoplasmic ribonucleoprotein granule
GO:0043232	intracellular non-membrane-bounded organelle
GO:0070062	extracellular exosome
GO:0070578	RISC-loading complex
GO:0098794	postsynapse
GO:0098978	glutamatergic synapse
GO:1990904	ribonucleoprotein complex

Cellular Component

P-body

nucleus

nucleoplasm

cytoplasm

cytosol