Structure of PDB 4z3d Chain A

Receptor sequence
>4z3dA (length=276) Species: 9606 (Homo sapiens) [Search protein sequence]
SSGIHVALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQ
AEGLSPRFHQLDIDDLQSIRALRDFLRKEYGGLDVLVNNAGIAFKVADPT
PFHIQAEVTMKTNFFGTRDVCTELLPLIKPQGRVVNVSSIMSVRALKSCS
PELQQKFRSETITEEELVGLMNKFVEDTKKGVHQKEGWPSSAYGVTKIGV
TVLSRIHARKLSEQRKGDKILLNACCPGWVRTDMAGPKATKSPEEGAETP
VYLALLPPDAEGPHGQFVSEKRVEQW
3D structure
PDB4z3d Structural insights on the catalytic site protection of human carbonyl reductase 1 by glutathione.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.184: carbonyl reductase (NADPH).
1.1.1.189: prostaglandin-E2 9-reductase.
1.1.1.196: 15-hydroxyprostaglandin-D dehydrogenase (NADP(+)).
1.1.1.197: 15-hydroxyprostaglandin dehydrogenase (NADP(+)).
1.1.1.71: alcohol dehydrogenase [NAD(P)(+)].
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GSH A F94 K95 Q105 S139 A192 Y193 F94 K95 Q105 S139 A192 Y193 MOAD: Ka=87200M^-1
BS02 NDP A G11 N13 K14 G15 I16 R37 R41 D62 D64 N89 A90 G91 I92 V137 Y193 K197 P227 G228 W229 V230 T232 M234 G11 N13 K14 G15 I16 R37 R41 D62 D64 N89 A90 G91 I92 V137 Y193 K197 P227 G228 W229 V230 T232 M234
Gene Ontology
Molecular Function
GO:0004090 carbonyl reductase (NADPH) activity
GO:0005515 protein binding
GO:0008106 alcohol dehydrogenase (NADP+) activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
GO:0047020 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity
GO:0047021 15-hydroxyprostaglandin dehydrogenase (NADP+) activity
GO:0050221 prostaglandin E2 9-reductase activity
GO:0160163 S-nitrosoglutathione reductase (NADPH) activity
Biological Process
GO:0006629 lipid metabolic process
GO:0006805 xenobiotic metabolic process
GO:0008211 glucocorticoid metabolic process
GO:0019371 cyclooxygenase pathway
GO:0030855 epithelial cell differentiation
GO:0042373 vitamin K metabolic process
GO:2000379 positive regulation of reactive oxygen species metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular exosome
GO:1903561 extracellular vesicle

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Cellular Component
External links
PDB RCSB:4z3d, PDBe:4z3d, PDBj:4z3d
PDBsum4z3d
PubMed26381805
UniProtP16152|CBR1_HUMAN Carbonyl reductase [NADPH] 1 (Gene Name=CBR1)

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