Structure of PDB 4z3a Chain A

Receptor sequence
>4z3aA (length=197) Species: 9606 (Homo sapiens) [Search protein sequence]
GSHMASFNGVSEAELLTKTLPDILTFNLDIVIIGINPGLMAAYKGHHYPG
PGNHFWKCLFMSGLSEVQLNHMDDHTLPGKYGIGFTNMVERTTPGSKDLS
SKEFREGGRILVQKLQKYQPRIAVFNGKCIYEIFSKEVFGVKVKNLEFGL
QPHKIPDTETLCYVMPSSSARCAQFPRAQDKVHYYIKLKDLRDQLKG
3D structure
PDB4z3a Thymine DNA glycosylase exhibits negligible affinity for nucleobases that it removes from DNA.
ChainA
Resolution1.72 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N140 H151
Catalytic site (residue number reindexed from 1) N36 H47
Enzyme Commision number 3.2.2.29: thymine-DNA glycosylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A G105 S106 H107 P155 K201 A274 A277 P280 R281 G1 S2 H3 P51 K97 A170 A173 P176 R177
BS02 dna A G105 N140 N157 G199 S200 K201 G231 K232 C233 S271 S273 A274 R275 C276 A277 Q278 G1 N36 N53 G95 S96 K97 G127 K128 C129 S167 S169 A170 R171 C172 A173 Q174
Gene Ontology
Molecular Function
GO:0000700 mismatch base pair DNA N-glycosylase activity
Biological Process
GO:0006285 base-excision repair, AP site formation

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Molecular Function
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Biological Process
External links
PDB RCSB:4z3a, PDBe:4z3a, PDBj:4z3a
PDBsum4z3a
PubMed26358812
UniProtQ13569|TDG_HUMAN G/T mismatch-specific thymine DNA glycosylase (Gene Name=TDG)

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