Structure of PDB 4z31 Chain A

Receptor sequence
>4z31A (length=293) Species: 9606 (Homo sapiens) [Search protein sequence]
NKHYEVAKKCVEDLALYLKPALSRPMQRKLVTLVNCQLVEEEGRVRAMRA
ARSLGERTVTELILQHQNPQQLSANLWAAVRARGCQFLGPAMQEEALKLV
LLALEDGSALSRKVLVLFVVQRLEPRFPQASKTSIGHVVQLLYRASCFKV
TKRDEDSSLMQLKEEFRSYEALRREHDAQIVHIAMEAGLRISPEQWSSLL
YGDLAHKSHMQSIIDKLQSPESFAKSVQELTIVLQRTGDPANLNRLRPHL
ELLANIDPNPDAVSPTWEQLENAMVAVKTVVHGLVDFIQNYSR
3D structure
PDB4z31 New Insights into the RNA-Binding and E3 Ubiquitin Ligase Activities of Roquins.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A S312 Q315 S316 D319 S208 Q211 S212 D215 PDBbind-CN: Kd=356nM
BS02 rna A R128 P129 R132 K133 R24 P25 R28 K29 PDBbind-CN: Kd=356nM
BS03 rna A R185 R187 R216 K217 S235 T237 Q244 Y247 R248 E259 D260 S261 S262 R81 R83 R112 K113 S131 T133 Q140 Y143 R144 E155 D156 S157 S158 PDBbind-CN: Kd=356nM
External links
PDB RCSB:4z31, PDBe:4z31, PDBj:4z31
PDBsum4z31
PubMed26489670
UniProtQ9HBD1|RC3H2_HUMAN Roquin-2 (Gene Name=RC3H2)

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