Structure of PDB 4z2t Chain A

Receptor sequence
>4z2tA (length=559) Species: 1437882 (Pseudomonas nitroreducens HBP1) [Search protein sequence]
AETDVLIVGAGPAGAMSATLLASLGIRSLMINRWRSTSPGPRSHIINQRT
MEILRDIGLEESAKSLAVPKEYMGEHVYATSLAGEEFGRIPAWASHPQAH
AEHELASPSRYCDLPQLYFEPMVVSEAALRGADVRFLTEYLGHVEDQDGV
TARLLDHVSGAEYEVRAKYIIGADGAHSLVAQNAGLPFEGQMGGSINIEF
SADLSSLCEHRKGDMYYMFVAALRMIRPWNKWICVWGEITKEEAKKIIHE
IIGTDEIPVEVGPISTWTINQQYAVRNTSGRVFCMGDAVHRHTPMGGLGL
NTSVQDAYNLAWKLALVLKGTAAPTLLDSYDAERSPVAKQIVERAFKSLS
TFPPVFEALSLPPAPTESEMAEALVRLKDASEEGAKRRAALRKAMDATII
GLGGGHGVELNQRYVSRAVFPDGTPDPGFVRDQEFFYQASTRPGAHLPHV
WLTENQRRISTLDLCGKGRFTLLTGLSGAAWKHEAEQVSQSLGIELKVCV
IGPGQEFVDTYGEYAKISEIGESGALLVRPDMFIAFRAKDASREGLEQLN
VAVKSILGR
3D structure
PDB4z2t A crystal structure of 2-hydroxybiphenyl 3-monooxygenase with bound substrate provides insights into the enzymatic mechanism.
ChainA
Resolution2.45 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H48 I251 P320
Catalytic site (residue number reindexed from 1) H44 I233 P294
Enzyme Commision number 1.14.13.44: 2-hydroxybiphenyl 3-monooxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A V12 G13 G15 P16 N36 R37 W38 R46 S47 Q120 E143 Y144 A177 D178 G179 W293 G312 D313 P320 V8 G9 G11 P12 N32 R33 W34 R42 S43 Q116 E139 Y140 A173 D174 G175 W267 G286 D287 P294
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004497 monooxygenase activity
GO:0016491 oxidoreductase activity
GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
GO:0071949 FAD binding

View graph for
Molecular Function
External links
PDB RCSB:4z2t, PDBe:4z2t, PDBj:4z2t
PDBsum4z2t
PubMed26275805
UniProtO06647

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