Structure of PDB 4z2c Chain A

Receptor sequence
>4z2cA (length=485) Species: 1313 (Streptococcus pneumoniae) [Search protein sequence]
QDKNLVNVNLTKEMKASFIDYAMSVIVARALPDVRDGLKPVHRRILYGMN
ELGVTPDKPHKKSARITGDVMGKYHPHGDSSIYEAMVRMAQWWSYRYMLV
DGHGNFGSMDGDSAAAQRYTEARMSKIALEMLRDINKNTVDFVDNYDANE
REPLVLPARFPNLLVNGATGIAVGMATNIPPHNLGETIDAVKLVMDNPEV
TTKDLMEVLPGPDFPTGALVMGKSGIHKAYETGKGSIVLRSRTEIETTKT
GRERIVVTEFPYMVNKTKVHEHIVRLVQEKRIEGITAVRDESNREGVRFV
IEVKRDASANVILNNLFKMTQMQTNFGFNMLAIQNGIPKILSLRQILDAY
IEHQKEVVVRRTRFDKEKAEARAHILEGLLIALDHIDEVIRIIRASETDA
EAQAELMSKFKLSERQSQAILDMRLRRLTGLERDKIQSEYDDLLALIADL
ADILAKPERVSQIIKDELDEVKRKFSDKRRTELMV
3D structure
PDB4z2c Structural studies of the drug-stabilized cleavage complexes of topoisomerase IV and gyrase from Streptococcus pneumoniae
ChainA
Resolution3.19 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A R30 K40 H43 H76 H78 R89 I172 R29 K39 H42 H75 H77 R88 I171
BS02 dna A I172 G175 M176 I171 G174 M175
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4z2c, PDBe:4z2c, PDBj:4z2c
PDBsum4z2c
PubMed
UniProtQ8DPM2|GYRA_STRR6 DNA gyrase subunit A (Gene Name=gyrA)

[Back to BioLiP]