Structure of PDB 4z2b Chain A

Receptor sequence
>4z2bA (length=449) Species: 9606 (Homo sapiens) [Search protein sequence]
PPAFTELQLPRYIMAGFPVCPKLSLEFGDPASSLFRWYKEAKPGAAEPEV
GVPSSLSPSSPSSSWTETDVEERVYTPSNADIGLRLKLHCTPGDGQRFGH
SRELESVCVVEAGPGTCTFDHRHLYTKKVTEDALIRTVSYNILADTYAQT
EFSRTVLYPYCAPYALELDYRQNLIQKELTGYNADVICLQEVDRAVFSDS
LVPALEAFGLEGVFRIKQHEGLATFYRKSKFSLLSQHDISFYEALESDPL
HKELLEKLVLYPSAQEKVLQRSSVLQVSVLQSTKDSSKRICVANTHLYWH
PKGGYIRLIQMAVALAHIRHVSCDLYPGIPVIFCGDFNSTPSTGMYHFVI
NGSIPEDHEDWASNGEEERCNMSLTHFFKLKSACGEPAYTNYVGGFHGCL
DYIFIDLNALEVEQVIPLPSHEEVTTHQALPSVSHPSDHIALVCDLKWK
3D structure
PDB4z2b The Role of Phosphodiesterase 12 (PDE12) as a Negative Regulator of the Innate Immune Response and the Discovery of Antiviral Inhibitors.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.13.4: poly(A)-specific ribonuclease.
3.1.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4LC A Y307 E351 W459 P461 N498 F556 Y147 E191 W299 P301 N338 F396 MOAD: Ki=17.5nM
PDBbind-CN: -logKd/Ki=7.76,Ki=17.5nM
Gene Ontology
Molecular Function
GO:0003824 catalytic activity

View graph for
Molecular Function
External links
PDB RCSB:4z2b, PDBe:4z2b, PDBj:4z2b
PDBsum4z2b
PubMed26055709
UniProtQ6L8Q7|PDE12_HUMAN 2',5'-phosphodiesterase 12 (Gene Name=PDE12)

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