Structure of PDB 4z0g Chain A

Receptor sequence
>4z0gA (length=384) Species: 284811 (Eremothecium gossypii ATCC 10895) [Search protein sequence]
TYRDAATALEHLATYAEKDGLSVEQLMDRGGLTYNDFLVLPGKIDFPSSE
VVLSSRLTKKITLNAPFVSSPMDTVTEADMAIHMALLGGIGIIHHNCTAE
EQAEMVRRVKKYENDGPLASKSADTKQLLCGAAIGTIDADRQRLAMLVEA
GLDVVVLDSSQGNSVFQINMIKWIKETFPDLQVIAGNVVTREQAASLIHA
GADGLRIGMGSGSICITQEVMACGRPQGTAVYNVTQFANQFGVPCIADGG
VQNIGHITKAIALGASTVMMGGMLAGTTESPGEYFFRGKRLKTYRGMGSI
DAMQKVLVAQGVTGSVIDKGSIKKYIPYLYNGLQHSCQDIGVRSLVEFRE
KVDSGSVRFEFRTPSAQLEGGVHNLHSYEKRLFD
3D structure
PDB4z0g Guanine nucleotide binding to the Bateman domain mediates the allosteric inhibition of eukaryotic IMP dehydrogenases.
ChainA
Resolution1.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.205: IMP dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5GP A S74 M76 R325 G331 S332 I333 C334 T336 D367 G390 G391 Y414 G416 M417 G418 Q448 S70 M72 R206 G212 S213 I214 C215 T217 D248 G271 G272 Y294 G296 M297 G298 Q310 MOAD: Ki=600uM
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0003938 IMP dehydrogenase activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0006164 purine nucleotide biosynthetic process

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4z0g, PDBe:4z0g, PDBj:4z0g
PDBsum4z0g
PubMed26558346
UniProtQ756Z6

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