Structure of PDB 4z07 Chain A

Receptor sequence
>4z07A (length=260) Species: 9606 (Homo sapiens) [Search protein sequence]
SHVTLPFYPKSPQSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGK
DSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCT
RTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLP
EEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVTREDSPSE
DPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVTCLVIDRDSFKHLIG
GLDDVSNKAY
3D structure
PDB4z07 Crystal Structure of PKG I:cGMP Complex Reveals a cGMP-Mediated Dimeric Interface that Facilitates cGMP-Induced Activation.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.12: cGMP-dependent protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PCG A V165 L172 F181 G182 E183 L184 A185 R192 T193 A194 V74 L81 F90 G91 E92 L93 A94 R101 T102 A103 PDBbind-CN: -logKd/Ki=7.99,Kd=10.3nM
BS02 PCG A V283 L296 R297 F305 G306 E307 K308 A309 R316 T317 A318 Y351 V192 L205 R206 F214 G215 E216 K217 A218 R225 T226 A227 Y260 PDBbind-CN: -logKd/Ki=7.99,Kd=10.3nM
Gene Ontology
Molecular Function
GO:0004692 cGMP-dependent protein kinase activity
GO:0005524 ATP binding
GO:0008603 cAMP-dependent protein kinase regulator activity
Biological Process
GO:0001932 regulation of protein phosphorylation
Cellular Component
GO:0005952 cAMP-dependent protein kinase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4z07, PDBe:4z07, PDBj:4z07
PDBsum4z07
PubMed27066748
UniProtQ13976|KGP1_HUMAN cGMP-dependent protein kinase 1 (Gene Name=PRKG1)

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