Structure of PDB 4yzn Chain A

Receptor sequence
>4yznA (length=269) Species: 44689 (Dictyostelium discoideum) [Search protein sequence]
PTLADNEIEYEKQIGKGGFGLVHKGRLVKDKSVVAIKSLILETEMIEKFQ
EFQREVFIMSNLNHPNIVKLYGLMHNPPRMVMELVPCGDLYHRLLDKAHP
IKWSVKLRLMLDIALGIEYMQNQNPPIVHRDLRSPNILLQSLDENAPVCA
KVADFGLSQQSVHSVSGLLGNFQWMAPETIGAEEESYTEKADTYSFAMIL
YTILTGEGPFDEYSYGKIKFINMIREEGLRPTIPEDCPPRLRNVIELCWS
GDPKKRPHFSYIVKELSEL
3D structure
PDB4yzn Structural Characterization of LRRK2 Inhibitors.
ChainA
Resolution1.55 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D1154 R1156 P1158 N1159 D1177 N1194
Catalytic site (residue number reindexed from 1) D131 R133 P135 N136 D154 N171
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4K5 A I1032 V1108 P1109 G1111 L1161 I14 V85 P86 G88 L138 MOAD: ic50=15.4uM
PDBbind-CN: -logKd/Ki=4.81,IC50=15.4uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4yzn, PDBe:4yzn, PDBj:4yzn
PDBsum4yzn
PubMed25897865
UniProtQ6XHB2|ROCO4_DICDI Probable serine/threonine-protein kinase roco4 (Gene Name=roco4)

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