Structure of PDB 4yzm Chain A

Receptor sequence
>4yzmA (length=260) Species: 44689 (Dictyostelium discoideum) [Search protein sequence]
RLPTLADNEIEYEKQIGKGGFGLVHKGRLVKDKSVVAIKSLILTEMIEKF
QEFQREVFIMSNLNHPNIVKLYGLMHNPPRMVMELVPCGDLYHRLLDKAH
PIKWSVKLRLMLDIALGIEYMQNQNPPIVHRDLRSPNILLQSLDENAPVC
AKVADFGLSQQLGNFQWMAPETIGAEEYTEKADTYSFAMILYTILTGEGP
FDEYSYGKIKFINMIREEGLRPTIPEDCPPRLRNVIELCWSGDPKKRPHF
SYIVKELSEL
3D structure
PDB4yzm Structural Characterization of LRRK2 Inhibitors.
ChainA
Resolution3.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D1154 R1156 P1158 N1159 D1177 N1194
Catalytic site (residue number reindexed from 1) D132 R134 P136 N137 D155 N164
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4K4 A I1032 G1035 K1055 M1105 E1106 L1107 V1108 P1109 G1111 L1161 I16 G19 K39 M83 E84 L85 V86 P87 G89 L139 PDBbind-CN: -logKd/Ki=5.27,IC50=5.38uM
BS02 MG A D1154 D1177 D132 D155
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4yzm, PDBe:4yzm, PDBj:4yzm
PDBsum4yzm
PubMed25897865
UniProtQ6XHB2|ROCO4_DICDI Probable serine/threonine-protein kinase roco4 (Gene Name=roco4)

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