Structure of PDB 4yzc Chain A

Receptor sequence
>4yzcA (length=385) Species: 9606 (Homo sapiens) [Search protein sequence]
SVVIVGKISFCPKDVLGHGAEGTIVYRGMFDNRDVAVKRILPDREVQLLR
ESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQEPITLLQQTTSG
LAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVRHSFS
RRSGVPGTEGWIAPEMLSCKENPTYTVDIFSAGCVFYYVISEGSHPFGKS
LQRQANILLGACSLDCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLK
HPFFWSLEKQLQFFQDVSDRIEKESLDGPIVKQLERGGRAVVKMDWRENI
TVPLQTDLRKFRTYKGGSVRDLLRAMRNKKHHYRELPAEVRETLGSLPDD
FVCYFTSRFPHLLAHTYRAMELCSHERLFQPYYFH
3D structure
PDB4yzc Long-Range Inhibitor-Induced Conformational Regulation of Human IRE1 alpha Endoribonuclease Activity.
ChainA
Resolution2.494 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D688 K690 N693 D711 T734
Catalytic site (residue number reindexed from 1) D113 K115 N118 D136 T158
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
3.1.26.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 STU A L577 V586 A597 K599 I642 L644 C645 H692 L695 L16 V25 A36 K38 I75 L77 C78 H117 L120 MOAD: ic50=3nM
PDBbind-CN: -logKd/Ki=8.52,IC50=3nM
Gene Ontology
Molecular Function
GO:0004521 RNA endonuclease activity
GO:0004540 RNA nuclease activity
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006397 mRNA processing
GO:0006468 protein phosphorylation
GO:0030968 endoplasmic reticulum unfolded protein response

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4yzc, PDBe:4yzc, PDBj:4yzc
PDBsum4yzc
PubMed26438213
UniProtO75460|ERN1_HUMAN Serine/threonine-protein kinase/endoribonuclease IRE1 (Gene Name=ERN1)

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