Structure of PDB 4yz3 Chain A

Receptor sequence
>4yz3A (length=654) Species: 170187 (Streptococcus pneumoniae TIGR4) [Search protein sequence]
TPVLEKNNVTLTGGGENVTKELKDKFTSGDFTVVIKYNQSSEKGLQALFG
ISNSKPGQQNSYVDVFLRDNGELGMEARDTSSNKNNLVSRPASVWGKYKQ
EAVTNTVAVVADSVKKTYSLYANGTKVVEKKVDNFLNIKDIKGIDYYMLG
GVKRAGKTAFGFNGTLENIKFFNSALDEETVKKMTTNAVTGHLIYTANDT
TGSNYFRIPVLYTFSNGRVFSSIDARYGGTHDFLNKINIATSYSDDNGKT
WTKPKLTLAFDDFAPVPLEWPREVGGRDLQISGGATYIDSVIVEKKNKQV
LMFADVMPAGVSFREATRKDSGYKQIDGNYYLKLRKQGDTDYNYTIRENG
TVYDDRTNRPTEFSVDKNFGIKQNGNYLTVEQYSVSFKKTEYRNGTKVHM
NIFYKDALFKVVPTNYIAYISSNDHGESWSAPTLLPPIMGLNRNAPYLGP
GRGIIESSTGRILIPSYTGKESAFIYSDDNGASWKVKVVPLPSSWSAEAQ
FVELSPGVIQAYMRTNNGKIAYLTSKDAGTTWSAPEYLKFVSNPSYGTQL
SIINYSQLIDGKKAVILSTPNSTNGRKHGQIWIGLINDDNTIDWRYHHDV
DYSNYGYSYSTLTELPNHEIGLMFEKFDSWSRNELHMKNVVPYITFKIED
LKKN
3D structure
PDB4yz3 Crystal Structure of Streptococcus pneumoniae NanC.
ChainA
Resolution2.38 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D315 E584 Y695
Catalytic site (residue number reindexed from 1) D232 E498 Y609
Enzyme Commision number 3.2.1.18: exo-alpha-sialidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 G39 A R290 D315 D372 Y553 R600 R662 Y695 W716 R207 D232 D289 Y467 R514 R576 Y609 W630
Gene Ontology
Molecular Function
GO:0004308 exo-alpha-sialidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006689 ganglioside catabolic process
GO:0009313 oligosaccharide catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4yz3, PDBe:4yz3, PDBj:4yz3
PDBsum4yz3
PubMed
UniProtA0A0H2UQE4

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