Structure of PDB 4yz2 Chain A

Receptor sequence
>4yz2A (length=655) Species: 1313 (Streptococcus pneumoniae) [Search protein sequence]
TPVLEKNNVTLTGGGENVTKELKDKFTSGDFTVVIKYNQSSEKGLQALFG
ISNSKPGQQNSYVDVFLRDNGELGMEARDTSSNKNNLVSRPASVWGKYKQ
EAVTNTVAVVADSVKKTYSLYANGTKVVEKKVDNFLNIKDIKGIDYYMLG
GVKRAGKTAFGFNGTLENIKFFNSALDEETVKKMTTNAVTGHLIYTANDT
TGSNYFRIPVLYTFSNGRVFSSIDARYGGTHDFLNKINIATSYSDDNGKT
WTKPKLTLAFDDFAPVPLEWPREVGGRDLQISGGATYIDSVIVEKKNKQV
LMFADVMPAGVSFREATRKDSGYKQIDGNYYLKLRKQGDTDYNYTIRENG
TVYDDRTNRPTEFSVDKNFGIKQNGNYLTVEQYSVSFEKKTEYRNGTKVH
MNIFYKDALFKVVPTNYIAYISSNDHGESWSAPTLLPPIMGLNRNAPYLG
PGRGIIESSTGRILIPSYTGKESAFIYSDDNGASWKVKVVPLPSSWSAEA
QFVELSPGVIQAYMRTNNGKIAYLTSKDAGTTWSAPEYLKFVSNPSYGTQ
LSIINYSQLIDGKKAVILSTPNSTNGRKHGQIWIGLINDDNTIDWRYHHD
VDYSNYGYSYSTLTELPNHEIGLMFEKFDSWSRNELHMKNVVPYITFKIE
DLKKN
3D structure
PDB4yz2 Streptococcus pneumoniae NanC: STRUCTURAL INSIGHTS INTO THE SPECIFICITY AND MECHANISM OF A SIALIDASE THAT PRODUCES A SIALIDASE INHIBITOR.
ChainA
Resolution2.06 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D315 E584 Y695
Catalytic site (residue number reindexed from 1) D232 E499 Y610
Enzyme Commision number 3.2.1.18: exo-alpha-sialidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DAN A R290 D315 I371 D372 F396 Y553 S582 R600 R662 Y695 R207 D232 I288 D289 F313 Y468 S497 R515 R577 Y610
Gene Ontology
Molecular Function
GO:0004308 exo-alpha-sialidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006689 ganglioside catabolic process
GO:0009313 oligosaccharide catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4yz2, PDBe:4yz2, PDBj:4yz2
PDBsum4yz2
PubMed26370075
UniProtA0A0H2UQE4

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