Structure of PDB 4yxm Chain A

Receptor sequence
>4yxmA (length=349) Species: 2336 (Thermotoga maritima) [Search protein sequence]
VPQELIEKIKLISPGTELRKALDDIINANFGALIFLVDDPKKYEDVIQGG
FWLDTDFSAEKLYELSKMNGAIVLSEDITKIYYANVHLVPDPTIPTGETG
TRHRTAERLAKQTGKVVIAVSRRRNIISLYYKNYKYVVNQVDFLISKVTQ
AISTLEKYKDNFNKLLSELEVLELENRVTLADVVRTLAKGFELLRIVEEI
RPYIVELGEEGRLARMQLRELTEDVDDLLVLLIMDYSSEEVEEETAQNIL
QDFITRREPSPISISRVLGYDVQQAAQLDDVLVSARGYRLLKTVARIPLS
IGYNVVRMFKTLDQISKASVEDLKKVEGIGEKRARAISESISSLKHRKT
3D structure
PDB4yxm Structural analysis of the diadenylate cyclase reaction of DNA-integrity scanning protein A (DisA) and its inhibition by 3'-dATP.
ChainA
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.85: diadenylate cyclase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2BA A L39 N75 G76 H93 L94 T107 R108 T111 L33 N69 G70 H87 L88 T101 R102 T105
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004016 adenylate cyclase activity
GO:0005524 ATP binding
GO:0016779 nucleotidyltransferase activity
GO:0106408 diadenylate cyclase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:4yxm, PDBe:4yxm, PDBj:4yxm
PDBsum4yxm
PubMed26014055
UniProtQ9WY43|DISA_THEMA DNA integrity scanning protein DisA (Gene Name=disA)

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