Structure of PDB 4yxd Chain A

Receptor sequence

>4yxdA (length=613) Species: 9823 (Sus scrofa)

STQYPVVDHEFDAVVVGAGGAGLRAAFGLSEAGFNTACVTKLFPTRSHTV
AAQGGINAALGNMEEDNWRWHFYDTVKGSDWLGDQDAIHYMTEQAPASVV
ELENYGMPFSRTEDGKIYQRAFGGQSLKFGKGGQAHRCCCVADRTGHSLL
HTLYGRSLRYDTSYFVEYFALDLLMENGECRGVIALCIEDGSIHRIRARN
TVVATGGYGRTYFSCTSAHTSTGDGTAMVTRAGLPCQDLEFVQFHPTGIY
GAGCLITEGCRGEGGILINSQGERFMERYAPVAKDLASRDVVSRSMTLEI
REGRGCGPEKDHVYLQLHHLPPEQLAVRLPGISETAMIFAGVDVTKEPIP
VLPTVHYNMGGIPTNYKGQVLRHVNGQDQVVPGLYACGEAACASVHGANR
LGANSLLDLVVFGRACALSIAESCRPGDKVPSIKPNAGEESVMNLDKLRF
ANGTIRTSELRLSMQKSMQSHAAVFRVGSVLQEGCEKILRLYGDLQHLKT
FDRGMVWNTDLVETLELQNLMLCALQTIYGAEARKESRGAHAREDFKERV
DEYDYSKPIQGQQKKPFQEHWRKHTLSYVDVKTGKVSLEYRPVIDKTLNE
ADCATVPPAIRSY

3D structure

• PDB: 4yxd Structural Insights into the Molecular Design of Flutolanil Derivatives Targeted for Fumarate Respiration of Parasite Mitochondria
• Chain: A
• Resolution: 3.0 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): F131 Q252 H254 L264 E267 R270 R298 H365 Y366 R409
• Catalytic site (residue number reindexed from 1): F122 Q243 H245 L255 E258 R261 R289 H356 Y357 R400
• Enzyme Commision number: 1.3.5.1: succinate dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	A	G26 A27 G28 T49 K50 L51 S56 H57 T58 A61 G63 G64 Y177 F178 A179 A213 T214 G215 T225 D233 L264 H365 Y366 G397 E398 R409 A412 S414 L415 L418	G17 A18 G19 T40 K41 L42 S47 H48 T49 A52 G54 G55 Y168 F169 A170 A204 T205 G206 T216 D224 L255 H356 Y357 G388 E389 R400 A403 S405 L406 L409

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0008177 succinate dehydrogenase (quinone) activity
• GO:0009055 electron transfer activity
• GO:0016491 oxidoreductase activity
• GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
• GO:0050660 flavin adenine dinucleotide binding

Biological Process

• GO:0006099 tricarboxylic acid cycle
• GO:0006121 mitochondrial electron transport, succinate to ubiquinone
• GO:0022900 electron transport chain

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0045273 respiratory chain complex II (succinate dehydrogenase)

External links

• PDB: RCSB:4yxd, PDBe:4yxd, PDBj:4yxd
• PDBsum: 4yxd
• PubMed: 26198225
• UniProt: Q0QF01|SDHA_PIG Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (Gene Name=SDHA)