Structure of PDB 4ywj Chain A

Receptor sequence

>4ywjA (length=268) Species: 208964 (Pseudomonas aeruginosa PAO1)

MRRIAVVGAAGRMGKNLIEAVQQTGGAAGLTAAVDRPDSTLVGADAGELA
GLGRIGVPLSGDLGKVCEEFDVLIDFTHPSVTLKNIEQCRKARRAMVIGT
TGFSADEKLLLAEAAKDIPIVFAANFSVGVNLCLKLLDTAARVLGDEVDI
EIIEAHHRHKVDAPSGTALRMGEVVAQALGRDLQEVAVYGREGQTGARAR
ETIGFATVRAGDVVGDHTVLFAAEGERVEITHKASSRMTFARGAVRAALW
LEGKENGLYDMQDVLGLR

3D structure

• PDB: 4ywj Crystal structure of 4-hydroxy-tetrahydrodipicolinate reductase (HTPA reductase) from Pseudomonas aeruginosa
• Chain: A
• Resolution: 1.8 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): H156 K160
• Catalytic site (residue number reindexed from 1): H156 K160
• Enzyme Commision number: 1.17.1.8: 4-hydroxy-tetrahydrodipicolinate reductase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAD	A	G11 R12 M13 D35 R36 F76 T77 V81 G99 T101 A124 N125 F126 R237 F240	G11 R12 M13 D35 R36 F76 T77 V81 G99 T101 A124 N125 F126 R237 F240

Gene Ontology

Molecular Function

• GO:0008839 4-hydroxy-tetrahydrodipicolinate reductase
• GO:0016491 oxidoreductase activity
• GO:0016726 oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor
• GO:0050661 NADP binding
• GO:0051287 NAD binding

Biological Process

• GO:0009085 lysine biosynthetic process
• GO:0009089 lysine biosynthetic process via diaminopimelate
• GO:0019877 diaminopimelate biosynthetic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:4ywj, PDBe:4ywj, PDBj:4ywj
• PDBsum: 4ywj
• UniProt: P38103|DAPB_PSEAE 4-hydroxy-tetrahydrodipicolinate reductase (Gene Name=dapB)