Structure of PDB 4yv0 Chain A

Receptor sequence
>4yv0A (length=269) Species: 353153 (Trypanosoma cruzi strain CL Brener) [Search protein sequence]
GWFREEPGQAMSLRVEKVLYDAPTKFQHLTIFESDPKGPWGTVMALDGCI
QVTDYDEFVYHEVLGHTSLCSHPKPERVLIIGGGDGGVLREVLRHGTVEH
CDLVDIDGEVMEQSKQHFPQISRSLADPRATVRVGDGLAFVRQTPDNTYD
VVIIDTTAFYKDVLRILKPDGICCNQGESIWLDLELIEKMSRFIRETGFA
SVQYALMHVPTYPCGSIGTLVCSKKAGVDVTKPLRPVEDMPFAKDLKYYD
SEMHKASFALPRFARHINN
3D structure
PDB4yv0 Structural insights into the novel inhibition mechanism of Trypanosoma cruzi spermidine synthase
ChainA
Resolution1.95 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.5.1.16: spermidine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 S4M A L59 Q64 Y73 H74 G95 D98 D118 I119 G150 D168 T169 T170 L46 Q51 Y60 H61 G82 D85 D105 I106 G137 D155 T156 T157
BS02 4JW A E14 M24 L26 W53 P235 T236 E5 M11 L13 W40 P210 T211 PDBbind-CN: -logKd/Ki=3.28,IC50=530uM
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004766 spermidine synthase activity
GO:0016740 transferase activity
Biological Process
GO:0006596 polyamine biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4yv0, PDBe:4yv0, PDBj:4yv0
PDBsum4yv0
PubMed26327378
UniProtQ4DA73

[Back to BioLiP]