Structure of PDB 4yuy Chain A

Receptor sequence
>4yuyA (length=293) Species: 353153 (Trypanosoma cruzi strain CL Brener) [Search protein sequence]
PGSELISGGWFREENDQWPGQAMSLRVEKVLYDAPTKFQHLTIFESDPKG
PWGTVMALDGCIQVTDYDEFVYHEVLGHTSLCSHPKPERVLIIGGGDGGV
LREVLRHGTVEHCDLVDIDGEVMEQSKQHFPQISRSLADPRATVRVGDGL
AFVRQTPDNTYDVVIIDTTDPAGPASKLFGEAFYKDVLRILKPDGICCNQ
GESIWLDLELIEKMSRFIRETGFASVQYALMHVPTYPCGSIGTLVCSKKA
GVDVTKPLRPVEDMPFAKDLKYYDSEMHKASFALPRFARHINN
3D structure
PDB4yuy Structural insights into the novel inhibition mechanism of Trypanosoma cruzi spermidine synthase.
ChainA
Resolution1.58 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.16: spermidine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 S4M A L59 Q64 H74 D98 D118 I119 V123 D149 G150 D168 T169 T170 P175 A176 L179 L58 Q63 H73 D97 D117 I118 V122 D148 G149 D167 T168 T169 P174 A175 L178
BS02 1SQ A I63 Q64 Y73 Q201 I62 Q63 Y72 Q200 MOAD: ic50=460uM
PDBbind-CN: -logKd/Ki=3.34,IC50=460uM
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004766 spermidine synthase activity
GO:0016740 transferase activity
Biological Process
GO:0006596 polyamine biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4yuy, PDBe:4yuy, PDBj:4yuy
PDBsum4yuy
PubMed26327378
UniProtQ4DA73

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