Structure of PDB 4yux Chain A

Receptor sequence
>4yuxA (length=293) Species: 353153 (Trypanosoma cruzi strain CL Brener) [Search protein sequence]
PGSELISGGWFREENDQWPGQAMSLRVEKVLYDAPTKFQHLTIFESDPKG
PWGTVMALDGCIQVTDYDEFVYHEVLGHTSLCSHPKPERVLIIGGGDGGV
LREVLRHGTVEHCDLVDIDGEVMEQSKQHFPQISRSLADPRATVRVGDGL
AFVRQTPDNTYDVVIIDTTDPAGPASKLFGEAFYKDVLRILKPDGICCNQ
GESIWLDLELIEKMSRFIRETGFASVQYALMHVPTYPCGSIGTLVCSKKA
GVDVTKPLRPVEDMPFAKDLKYYDSEMHKASFALPRFARHINN
3D structure
PDB4yux Structural insights into the novel inhibition mechanism of Trypanosoma cruzi spermidine synthase.
ChainA
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.16: spermidine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 S4M A Q40 Q64 H74 D98 D118 I119 V123 G150 D168 T169 T170 P175 A176 L179 Q39 Q63 H73 D97 D117 I118 V122 G149 D167 T168 T169 P174 A175 L178
BS02 4JT A I63 Q64 Y73 Q201 T236 I242 I62 Q63 Y72 Q200 T235 I241 MOAD: ic50=180uM
PDBbind-CN: -logKd/Ki=3.74,IC50=180uM
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004766 spermidine synthase activity
GO:0016740 transferase activity
Biological Process
GO:0006596 polyamine biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4yux, PDBe:4yux, PDBj:4yux
PDBsum4yux
PubMed26327378
UniProtQ4DA73

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