Structure of PDB 4yuw Chain A

Receptor sequence
>4yuwA (length=294) Species: 353153 (Trypanosoma cruzi strain CL Brener) [Search protein sequence]
MPGSELISGGWFREENDQWPGQAMSLRVEKVLYDAPTKFQHLTIFESDPK
GPWGTVMALDGCIQVTDYDEFVYHEVLGHTSLCSHPKPERVLIIGGGDGG
VLREVLRHGTVEHCDLVDIDGEVMEQSKQHFPQISRSLADPRATVRVGDG
LAFVRQTPDNTYDVVIIDTTDPAGPASKLFGEAFYKDVLRILKPDGICCN
QGESIWLDLELIEKMSRFIRETGFASVQYALMHVPTYPCGSIGTLVCSKK
AGVDVTKPLRPVEDMPFAKDLKYYDSEMHKASFALPRFARHINN
3D structure
PDB4yuw Structural insights into the novel inhibition mechanism of Trypanosoma cruzi spermidine synthase.
ChainA
Resolution1.97 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.16: spermidine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 S4M A Q40 Q64 Y73 H74 G95 D98 D118 I119 D149 G150 D168 T169 T170 P175 A176 L179 Q40 Q64 Y73 H74 G95 D98 D118 I119 D149 G150 D168 T169 T170 P175 A176 L179
BS02 4JU A Q64 T169 D171 Q201 Y237 Q64 T169 D171 Q201 Y237 MOAD: ic50=1.7uM
PDBbind-CN: -logKd/Ki=5.77,IC50=1.7uM
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004766 spermidine synthase activity
GO:0016740 transferase activity
Biological Process
GO:0006596 polyamine biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4yuw, PDBe:4yuw, PDBj:4yuw
PDBsum4yuw
PubMed26327378
UniProtQ4DA73

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