Structure of PDB 4yur Chain A

Receptor sequence
>4yurA (length=226) Species: 9606 (Homo sapiens) [Search protein sequence]
IGEKIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMV
QRVQNEVKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNR
VKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIAD
FGLESDVWSLGCMFYTLLIGRPPFTVKNTLNKVVLADYEMPSFLSIEAKD
LIHQLLRRNPADRLSLSSVLDHPFMS
3D structure
PDB4yur Cell biology. Reversible centriole depletion with an inhibitor of Polo-like kinase 4.
ChainA
Resolution2.65 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D136 T138 S140 N141 D154
Catalytic site (residue number reindexed from 1) D132 T134 S136 N137 D150
Enzyme Commision number 2.7.11.21: polo kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4J7 A L18 G19 F23 R28 A39 E90 M91 C92 H93 G95 L143 L14 G15 F19 R24 A35 E86 M87 C88 H89 G91 L139 PDBbind-CN: -logKd/Ki=9.80,Ki=0.16nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4yur, PDBe:4yur, PDBj:4yur
PDBsum4yur
PubMed25931445
UniProtO00444|PLK4_HUMAN Serine/threonine-protein kinase PLK4 (Gene Name=PLK4)

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