Structure of PDB 4yt0 Chain A

Receptor sequence
>4yt0A (length=616) Species: 6253 (Ascaris suum) [Search protein sequence]
SNIAQYKVIDHAYDVVIIGAGGAGLRAAMGLGEAGFKTAVVTKMFPTRSH
TTAAQGGINAALGSMNPDDWKWHFYDTVKGSDWLGDQNAMHYLTRNAVEA
VTELENFGMPFSRTPEGKIYQRSFGGQSNNYGKGGVAKRTCCVADRTGHS
MLHTLYGNSLRCHCTFFIEYFALDLLMDKGRCVGVIALCLEDGTIHRFRS
KRTIVATGGYGRAYFSCTTAHMNTGDGTALATRAGIALEDLEFIQFHPTG
IYGVGCLITEGSRGEGGFLVNSEGERFMERYAPKAKDLASRDVVSRAETI
EIMEGRGVGPEKDHIYLQLHHLPAEQLHQRLPGISETAKIFAGVDVTKEP
IPVIPTVHYNMGGIPTNYKAQVIKYTKEGGDKIVPGLYACGECACHSVHG
ANRLGANSLLDAVVFGRACSINIKEELKPDEKIPELPEGAGEESIANLDA
VRYANGDVPTAELRLTMQKTMQKHAGVFRRGDILAEGVKKMMDLFKELKR
LKTTDRSLIWNSDLTESLELQNLMLNATQTIVAAENRKESRGAHARDDFP
KREDEYDYSKPIEGQTKRPFEKHWRKHTLTKQDPRTGHITLDYRPVIDKT
LDPAEVDWIPPIIRSY
3D structure
PDB4yt0 Structural Insights into the Molecular Design of Flutolanil Derivatives Targeted for Fumarate Respiration of Parasite Mitochondria
ChainA
Resolution3.66 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.3.5.1: succinate dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A I47 G48 A49 G50 A52 T71 K72 M73 S78 H79 T80 A83 Q84 G85 G86 A201 A235 T236 D255 L286 H387 Y388 G420 E421 R432 A435 S437 L438 I18 G19 A20 G21 A23 T42 K43 M44 S49 H50 T51 A54 Q55 G56 G57 A172 A206 T207 D226 L257 H358 Y359 G391 E392 R403 A406 S408 L409
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0005515 protein binding
GO:0008177 succinate dehydrogenase (quinone) activity
GO:0009055 electron transfer activity
GO:0016491 oxidoreductase activity
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0006099 tricarboxylic acid cycle
GO:0006121 mitochondrial electron transport, succinate to ubiquinone
GO:0022900 electron transport chain
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0031966 mitochondrial membrane
GO:0045273 respiratory chain complex II (succinate dehydrogenase)

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Molecular Function
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Cellular Component
External links
PDB RCSB:4yt0, PDBe:4yt0, PDBj:4yt0
PDBsum4yt0
PubMed26198225
UniProtQ33862|SDHA1_ASCSU Succinate dehydrogenase [rhodoquinone] flavoprotein subunit 1, mitochondrial (Gene Name=SDHA1)

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