Structure of PDB 4ysx Chain A

Receptor sequence

>4ysxA (length=616) Species: 6253 (Ascaris suum) [Search protein sequence]

SNIAQYKVIDHAYDVVIIGAGGAGLRAAMGLGEAGFKTAVVTKMFPTRSH
TTAAQGGINAALGSMNPDDWKWHFYDTVKGSDWLGDQNAMHYLTRNAVEA
VTELENFGMPFSRTPEGKIYQRSFGGQSNNYGKGGVAKRTCCVADRTGHS
MLHTLYGNSLRCHCTFFIEYFALDLLMDKGRCVGVIALCLEDGTIHRFRS
KRTIVATGGYGRAYFSCTTAHMNTGDGTALATRAGIALEDLEFIQFHPTG
IYGVGCLITEGSRGEGGFLVNSEGERFMERYAPKAKDLASRDVVSRAETI
EIMEGRGVGPEKDHIYLQLHHLPAEQLHQRLPGISETAKIFAGVDVTKEP
IPVIPTVHYNMGGIPTNYKAQVIKYTKEGGDKIVPGLYACGECACHSVHG
ANRLGANSLLDAVVFGRACSINIKEELKPDEKIPELPEGAGEESIANLDA
VRYANGDVPTAELRLTMQKTMQKHAGVFRRGDILAEGVKKMMDLFKELKR
LKTTDRSLIWNSDLTESLELQNLMLNATQTIVAAENRKESRGAHARDDFP
KREDEYDYSKPIEGQTKRPFEKHWRKHTLTKQDPRTGHITLDYRPVIDKT
LDPAEVDWIPPIIRSY

3D structure

PDB

4ysx Structural Insights into the Molecular Design of Flutolanil Derivatives Targeted for Fumarate Respiration of Parasite Mitochondria

Chain

Resolution

2.25 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

1.3.5.1: succinate dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	A	G48 A49 G50 A52 T71 K72 M73 S78 H79 T80 A83 Q84 G85 G86 A201 A235 T236 G237 D255 L286 H387 Y388 G420 E421 R432 A435 S437 L438	G19 A20 G21 A23 T42 K43 M44 S49 H50 T51 A54 Q55 G56 G57 A172 A206 T207 G208 D226 L257 H358 Y359 G391 E392 R403 A406 S408 L409

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0008177	succinate dehydrogenase (quinone) activity
GO:0009055	electron transfer activity
GO:0016491	oxidoreductase activity
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors
GO:0050660	flavin adenine dinucleotide binding

	Biological Process
GO:0006099	tricarboxylic acid cycle
GO:0006121	mitochondrial electron transport, succinate to ubiquinone
GO:0022900	electron transport chain

	Cellular Component
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0031966	mitochondrial membrane
GO:0045273	respiratory chain complex II (succinate dehydrogenase)

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:4ysx, PDBe:4ysx, PDBj:4ysx
PDBsum	4ysx
PubMed	26198225
UniProt	Q33862\|SDHA1_ASCSU Succinate dehydrogenase [rhodoquinone] flavoprotein subunit 1, mitochondrial (Gene Name=SDHA1)

[Back to BioLiP]